Leuprolide Acetate

Leuprolide Acetate

Product Name Leuprolide Acetate Cas No.74381-53-6 Sequence:Glp-His-Trp-Ser-Tyr-DLeu-Leu-Arg-Pro-NHEt Molecular Formula:C 59 H 84 N 16 O 12· nC 2 H 4 O 2 (n=1~2) Molar Mass:1209.4·n60.02 The Maximum Unspecified Impurity :≤0.2% Storage Temperature :Room temperature Packing...

Product Name

Leuprolide Acetate

Cas No.74381-53-6

Sequence:Glp-His-Trp-Ser-Tyr-DLeu-Leu-Arg-Pro-NHEt

Molecular Formula:C59H84N16O12· nC2H4O2(n=1~2)

Molar Mass:1209.4·n60.02

The Maximum Unspecified Impurity :≤0.2%

Storage Temperature :Room temperature

Packing Size:20G/Bottle,40G/Bottle or at customers reqirement.

 

CAS Number: 53714-56-0 (net), 74381-53-6 (acetate)

Molecular formula: C59H84N16O12
Molar mass: 1209.41
Sequence: Pyr-His-Trp-Ser-Tyr-D-Leu-Leu-Arg-Pro-NHEt
Medical use: Leuprolide is a manufactured version of a hormone used to treat prostate cancer, breast cancer, endometriosis, uterine fibroids, and early puberty.

 

Leuprolide is a synthetic 9 residue peptide analog of gonadotropin releasing hormone belonging to the class of drugs called hormones or hormone antagonists. It is used to treat advanced prostate cancer, uterine fibroids, and endometriosis (under investigation for possible use in the treatment of mild to moderate Alzheimer's disease). Leuprolide is also used to treat precocious puberty, control ovarian stimulation in in vitro fertilization (IVF), and for reducing sexual urges in pedophiles and other cases of paraphilia.

Indication

To treat prostate cancer, endometriosis, uterine fibroids, and premature puberty.

Pharmacodynamics

Leuprolide is a luteinizing hormone agonist that results in suppression of testicular or follicular steroidogenesis thus used in the palliative treatment of advanced prostate cancer.

Mechanism of Action

Leuprolide binds to the gonadotropin releasing hormone receptor and acts as an efficient inhibitor of gonadotropin secretion.

Metabolism

Primarily degraded by peptidase (instead of cytochrome P450 enzymes).

Clearance

Excretion in urine, 8.34 L/hour [healthy male receiving a 1-mg IV bolus]

Absorption

Bioavailability by subcutaneous administration is comparable to that by intravenous administration.

 

 
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