Product Name
Leuprolide Acetate
Cas No.74381-53-6
Sequence:Glp-His-Trp-Ser-Tyr-DLeu-Leu-Arg-Pro-NHEt
Molecular Formula:C59H84N16O12· nC2H4O2(n=1~2)
Molar Mass:1209.4·n60.02
The Maximum Unspecified Impurity :≤0.2%
Storage Temperature :Room temperature
Packing Size:20G/Bottle,40G/Bottle or at customers reqirement.
CAS Number: 53714-56-0 (net), 74381-53-6 (acetate)
Molecular formula: C59H84N16O12
Molar mass: 1209.41
Sequence: Pyr-His-Trp-Ser-Tyr-D-Leu-Leu-Arg-Pro-NHEt
Medical use: Leuprolide is a manufactured version of a hormone used to treat prostate cancer, breast cancer, endometriosis, uterine fibroids, and early puberty.
Leuprolide is a synthetic 9 residue peptide analog of gonadotropin releasing hormone belonging to the class of drugs called hormones or hormone antagonists. It is used to treat advanced prostate cancer, uterine fibroids, and endometriosis (under investigation for possible use in the treatment of mild to moderate Alzheimer's disease). Leuprolide is also used to treat precocious puberty, control ovarian stimulation in in vitro fertilization (IVF), and for reducing sexual urges in pedophiles and other cases of paraphilia.
Indication
To treat prostate cancer, endometriosis, uterine fibroids, and premature puberty.
Pharmacodynamics
Leuprolide is a luteinizing hormone agonist that results in suppression of testicular or follicular steroidogenesis thus used in the palliative treatment of advanced prostate cancer.
Mechanism of Action
Leuprolide binds to the gonadotropin releasing hormone receptor and acts as an efficient inhibitor of gonadotropin secretion.
Metabolism
Primarily degraded by peptidase (instead of cytochrome P450 enzymes).
Clearance
Excretion in urine, 8.34 L/hour [healthy male receiving a 1-mg IV bolus]
Absorption
Bioavailability by subcutaneous administration is comparable to that by intravenous administration.

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