Atosiban acetate is a disulfide-bonded cyclic polypeptide composed of 9 amino acids. It is an oxytocin molecule modified at positions 1, 2, 4 and 8. The N-terminal of the peptide is 3-mercaptopropionic acid (thiol and The sulfhydryl group of [Cys]6 forms a disulfide bond), the C-terminus is in the form of an amide, and the second amino acid at the N-terminus is [D-Tyr(Et)]2 modified by ethylation. Atosiban acetate is used in medicines as vinegar The common name is atosiban acetate.
Specifications
Colour:White to Off-White
Appearance: solid
Molecular Formula :C43H67N11O12S2
Molar Mass 994.199 g/mol
Purity ≥98%
Impurity ≤0.5%
Applications
Competitive antagonist of cyclic peptide oxytocin receptor in uterus and on decidua and fetal membranes.
Why Use Atosiban?
Atosiban is a combined receptor antagonist of oxytocin and vasopressin V1A, a receptor for oxytocin that is structurally similar to the V1A receptor for vasopressin. When the oxytocin receptor is blocked, oxytocin can still act through the V1A receptor, so it is necessary to block the above two receptor pathways at the same time, and a single antagonism of one receptor can effectively inhibit uterine contraction. This is also one of the main reasons why beta-receptor agonists, calcium ion channel blockers and prostaglandin synthase inhibitors cannot effectively inhibit uterine contractions.
Storage
-20°C
- Certificates
- INSTRUMENTS
- EQUIPMENTS
Hot Tags: atosiban acetate, China atosiban acetate manufacturers, factory, Sodium Erythorbate, Xanthan Gum Oil Drilling Grade, L Ascorbyl Palmitate L AP , Red Yeast Rice, tert-Butylhydroquinone, 1 2 Benzisothiazolin 3 one
