Peptides

Why Choose Us

Rich Experience

Founded in 2009, Shanghai Exquisite is a company specializing in the production and supply of APIs and chemicals.

Professional Technique

Our main products include peptide raw materials, custom peptides, cosmetic peptides, peptide formulations, solid dosage forms, medical devices, and peptide skincare products.

We have achieved significant regulatory milestones.

Quality Guaranteed

Our products obtaining GMP inspection certifications from various international authorities including NMPA (CFDA) of China, the US FDA, the EU's AEMPS, Brazil's ANVISA, and South Korea's MFDS.

Global Sales

Our products have been exported to Europe, the United States, India, South Asia, Southeast Asia and other regions, and have been recognized and highly praised by the market and customers.

First 12 3 4 5 6 Last 1/6

Definition of Peptides

Peptides are short chains of amino acids linked by peptide bonds. A polypeptide is a longer, continuous, unbranched peptide chain. Polypeptides which have a molecular mass of 10,000 Da or more are called proteins. Chains of fewer than twenty amino acids are called oligopeptides, and include dipeptides, tripeptides, and tetrapeptides.

Formation of Peptides

Peptides are formed by the peptide linkage between amino acids. let us understand the peptide formation by taking an example of dipeptide. For the formation of dipeptide, two amino acids approach each other and form a covalent bond between C1 – carbon of carboxylic acid and N2 – nitrogen atom of amino acid group by removal of the water molecule. One amino acid loses its hydrogen atom and another its hydroxyl group. It is a condensation reaction. The covalent linkage formed between two amino acids is called peptide bond (-CO-NH-) or peptide linkage. Formation of peptide bonds consumes energy. As the water molecule is getting removed, so it is a dehydration synthesis process.

Why Exquisite?

An Unique TIDEs Platform with Cutting Edge Technologies

As one of the industry leaders in therapeutic peptides, We are the leading API provider of Semaglutide, Tirzepatide, and Liraglutide worldwide, Exquisite not only consistently delivers the best quality peptide APIs, but also provides the most complete documentation meeting the highest global quality and regulatory requirement. Meanwhile, our advanced technologies in both process development and manufacturing enable Exquisite to produce these peptides in an extremely efficient manner with high yield and among the largest batch sizes known to date. Exquisite also excels in providing efficient, flexible, and high-quality end-to-end CRDMO services encompassing multiple modalities such as peptides, oligonucleotides, small molecules, and related synthetic conjugates etc. It makes Exquisite one of the most trusted worldwide partners in pharmaceutical and healthcare industries.

OUR ADVANTAGE

OUR ADVANTAGE

15+Years Experience of CDMO &CMO and regulated markets development

Never have GTl issues in last 10 years + recently 4-5 years

One Company for Global Markets:EU,US,CN&ROW

Multi-plants Location reduces local policy risk

High Compliance Guarantee for Supply Continuity

Well equipped EHS & Quality System

Risk Management: Strict supplier management; Bridge stock

Listed company, financial and technical support

GMP Service

01 High capacity

cGMP Facilities

Bulky-scale Solid & Solution Phase Synthesis

Proportionately Scaled HPLC Purification

Qualified Air and Water Systems

Cleanrooms around 8000m²

02 Our Standard GMPSpecifications

Appearance; Assay; ldentity (MS); Purity (HPLC); Solubility; Counter lon; Water Content;Amino Acid Analysis; Peptide Content; Chloride Content; Residual Organic Solvents;Bacterial Endotoxins; PH; Other API-specific Parameters

Service

Well Established & Experienced

Gost Effectiveness with Quality

High Qualified, Experienced &Professional Researchers

Tailor Made Solution with Data Integrity

Highest Confidentiality & Integrity on Every ProjectEfficient Reporting System & ReliabilityCollaboration with Medical & Government

Utmost Customer Satisfaction

Benefits of Peptides

Products-Cosmetic Peptides

Removing Expression Lines

ACETYL HEXAPEPTIDE-8

ACETYL OCTAPEPTIDE-3

DIPEPTIDE DIAMINOBUTYROYL BENZYLAMIDE

DIACETATE

BUTHOTOXIN

Anti-wrinkle & Anti-aging

PALMITOYL TRIPEPTIDE-5

PALMITOYL PENTAPEPTIDE-4

PALMITOYL TETRAPEPTIDE-7

PALMITOYL TRIPEPTIDE-1

PALMITOYL HEXAPEPTIDE-12

PALMITOYLTRIPEPTIDE-38

Whitening and Freckle Removing

NONPEPTIDE-1

TETRAPEPTIDE-30

CARNOSINE

Preventing Hair Loss andGrowing Eyelash

MYRISTOYL PENTAPEPTIDE-4

BOITINOYL TRIPEPTIDE-1

Repairing Skin

COPPER TRIPEPTIDE-1

PALMITOYL COPPER TRIPEPTIDE-1

MELITTIN

Enlarging Chest

ACETYL HEXAPEPTIDE-38

Removing Eyebags

ACETYL TETRAPEPTIDE-5

DIPEPTIDE-2

Anti-allergic

ACETYL TETRAPEPTIDE-15

Products-Customer Peptides

PEGylation

Reduced peptide bonds

Special or Non-natural AminO Acids: D-AMINO ACIDS, HOMO-AMINO ACIDS, N-METHYL AMINO ACIDS,ALPHA-METHYL AMINO ACIDS, CIT, HYP, NLE, ORN, NAL, ABU, DAB ETC

Branched MAPs (Multiple-Antigen Peptide): 4-BRANCH OR 8-BRANCH

C-terminal modifications:AMIDE, ALCOHOL, ALDEHYDE, BIOTINYL, PNA, AMC, AFC, CMK ETC

Conjugation to Carrier proteins: BSA, KLH, OVA

Disulfide bond (one disulfide bond or multiple disulfide bonds)

Labeling with Fluorescence or Dye: FITC, FAM, TAMRA, RHOADMINE, DANSYL ETC

terminal modifications:ACETYL, BIOTINYL, FORMYL, PYROGLUTAMYL, FATTY ACIDS ETC

Phosphorylation and sulfation:SER (PO3H2),THR (PO3H2),TYR(PO3H2) OR TYR (SO3H)

Peptide Synthesis

Crude, Desalted and purified peptides up to purity of 99%.

Peptide Modifications

Cyclization:SULFIDE BOND, HEAD TO TAIL OR SIDE CHAIN AMIDE BOND

Glycosylation

Labeling with Chelating Groups:DOTA,DTPA, NOTA ET

Labeling with stable isotopes:15N, 13C OR 2H

Main Products

01/

Semaglutide

CAS 910463-68-2

MF C187H291N45O59

MW 4113.57754

Purity 98%

Solubility Soluble in water

Appearance White or almost white powder

Storage Temp -15°C to -25°C

Indication Type II diabetes

Description

Semaglutide(910463-68-2) is an anti-diabetic medication that is sold under brand names such as Ozempic, Wegovy, and Rybelsus. It is used to treat type 2 diabetes and manage chronic weight. The drug functions similar to human glucagon-like peptide-1 (GLP-1) by increasing insulin secretion, which leads to improved sugar metabolism.

02/

Liraglutide

CAS 204656-20-2

MF C172H265N43O51

MW 3751.202

Purity 98%

Melting point >182°C (dec.)

Solubility DMSO (Slightly), Water (Slightly)

Appearance White to Off-White solid

Storage Temp Refrigerator

Description

Liraglutide is GLP-1(1–37) modified at Ly: the -amino group is acylated with an (N-hexadecanoyl)glutam- -yl moiety that noncovalently but avidly binds tohuman serum albumin. (Also, Lys is conservatively replacedwith Arg.)

03/

Copper Peptide

CAS 49557-75-7

MF C14H24N6O4

MW 340.38

Purity 98%

Melting point >144°C (dec.)

Solubility Aqueous Acid (Slightly), DMSO (Slightly

Appearance Solid Off-White

Storage Temp under inert gas (nitrogen or Argon) at 2–8 °C

Description

Copper peptide GHK-Cu is a naturally occurring copper complex of the tripeptide glycyl-L-histidyl-L-lysine

04/

Tirzepatide

CAS 2023788-19-2

MF C225H348N48O68

MW 4813.527

Purity 98%

Solubility DMSO

Appearance White powder

Storage Temp -20℃ ± 5℃

Indication Type II diabetes

Description

Tirzepatide (LY3298176) was developed as a dual agonist to both GLP-1 and gastric inhibitory polypeptide (GIP) receptors (Frias et al., 2018). Similar to GLP-1, GIP is an incretin hormone that functions to induce insulin secretion.

05/

Acetyl Octapeptide-3

CAS 868844-74-0

MF C41H70N16O16S

MW 1075.17

Purity 98%

Melting point 1.56

Solubility DMSO: 10mg/mL; PBS (pH 7.2): 10mg/mL

Appearance A solid

Storage Temp under inert gas (nitrogen or Argon) at 2–8 °C

Description

Acetyl Octapeptide-3, also known as SNAP-8, is a synthetic peptide that is based around octapeptide-3,

06/

Acetyl Tetrapeptide-5

CAS 820959-17-9

MF C20H28N8O7

MW 492.49

Purity 98%

Melting point 1.443

Solubility PBS (pH 7.2): 10 mg/ml

Appearance A crystalline solid

Storage Temp 2-8°C

Description

Acetyl Tetrapeptide-5 is a white to cream coloured powder

07/

Cagrilintide

CAS 1415456-99-3

MF C194H312N54O59S2

MW 4409 g/mol

Purity 98%

Description

Cagrilintide is an amylin-analog, now being developed in combination with the GLP-1 agonist semaglutide to achieve sustained weight loss in persons with overweight and obesity

08/

Retatrutide

CAS 2381089-83-2

MF C223H343F3N46O70

MW 4845.444

Purity 98%

Solubility Soluble in water

Appearance White lyophilized powder

Storage Temp -20°C

Indication Obesity

Description

Retatrutide is a novel triple agonist peptide of the glucagon receptor (GCGR), glucose-dependent insulinotropic polypeptide receptor (GIPR) and glucagon-like peptide-1 receptor (GLP-1R). Retatrutide inhibits human GCGR, GIPR and GLP-1R with EC50 values of 5.79, 0.0643 and 0.775 nM, respectively and mouse GCGR, GIPR, and GLP-1R with EC50 values of 2.32, 0.191 and 0.794 nM, respectively

Certifications

Our products obtaining GMP inspection certifications from various international authorities including NMPA (CFDA) of China, the US FDA, the EU's AEMPS, Brazil's ANVISA, and South Korea's MFDS.

Our Factory

Shanghai Exquisite Biochemical Co., Ltd. established in 2009, we are specializing in production and supply API and chemicals.

Frequently Asked Questions

Q: What are peptides used for?

A: Peptides are sold in dietary supplements including pills or protein shakes. They claim to help you build muscle, boost weight and fat loss, and help with muscle recovery. But there's little direct evidence to back up most of these statements. And it's not clear how well your body can absorb peptides from supplements.

Q: Are peptides a steroid?

A: Peptides and steroids are both similar yet polar opposites. The main difference, however, is that steroids increase testosterone levels unnaturally in the body whereas peptides simply increase the signal allowing the body to create more of this hormone naturally.

Q: What is the function of a peptide?

A: The fundamental nature of peptides as the building blocks of proteins, allow for the synthetic and in vitro mimicking of these endogenous substances to that regulate specific cellular functions and facilitate an innumerable amount of biochemical process in the body.

Q: What foods are high in peptides?

A: The most widely used animal proteins are from eggs, milk (casein and whey), and meat proteins. Bioactive peptides from plant sources are typically from soy, oat, pulses (chickpea, beans, peas, and lentils), canola, wheat, flaxseed, and hemp seed.

Q: Are peptides good or bad?

A: Peptides are generally considered safe, and while they're a promising skin care ingredient, more research is needed on their efficacy.

Q: Do peptides have side effects?

A: Reported side effects of peptides and hormones include: Water retention. Numbness of the hands and feet. Increased tiredness.

Q: Who needs peptides?

A: Peptides work to rebuild and repair damaged cells and signal skin to produce collagen, slowing the aging process. This is a go-to moisturizer for a large range of women and men, including those with sensitive, dry and acne-prone skin.

Q: Is creatine a peptide?

A: Creatine is a small peptide made of three amino-acids: glycine, arginine and methionine. This compound is first synthesised in the kidneys and finally in the liver. This natural synthesis of creatine is about 1 g per day.

Q: Is collagen a peptide?

A: Collagen peptides are very small pieces of protein from animal collagen. Collagen is one of the materials that makes up cartilage, bone, and skin. Collagen peptides are made by breaking down whole collagen proteins into smaller pieces. When taken by mouth, collagen peptides seem to build up in the skin and cartilage.

Q: Who should not take peptides?

A: Those who are pregnant, breastfeeding, taking medications, or living with a medical condition should avoid using peptides until they speak to their doctor.

Q: Do peptides increase testosterone?

A: In men, LH stimulates the production of testosterone. This peptide is used to boost testosterone in men who are not yet candidates for testosterone replacement therapy and to help maintain your own production of testosterone while on testosterone replacement therapy.

Q: What is the disadvantage of peptides?

A: Peptides have weak membrane permeability. The membrane permeability of peptide drugs depends on multiple factors, including peptide length and amino acid composition. Peptides are generally unable to cross the cell membrane to target intracellular targets, thus limiting their applications in drug development.

Q: What are the risks of peptides?

A: Injection Site Reactions: Peptides that are administered via injection can sometimes cause pain, swelling, and bruising at the injection site. Hormonal Imbalances: Peptides that affect hormone levels, such as growth hormone-releasing peptides, can lead to hormonal imbalances if not administered correctly.

Q: Which peptide is best for anti aging?

A: Epitalon.
GHK-Cu Basic.
Argireline.
Matrixyl.
P21.
L-Glutathione.
FOXO4-DRI.
Tripeptide-29.

Q: Do peptides affect your liver?

A: The effects of antifibrotic peptides demonstrate that peptides can be promising candidates for the treatment of liver fibrosis. However, a common problem with therapeutic peptides is their short half-life and susceptibility to metabolism, leading to limited applications.

Q: Do peptides affect the heart?

A: The heart not only secretes various cardiac peptides but is also a target organ expressing receptors for these cardiac peptides. It has been elucidated that these cardiac peptides play an important role in the pathophysiology of heart failure, and several of them indeed have been clinically applied.

Q: Are peptides addictive?

A: Overall, while there is currently no evidence to suggest that peptides are addictive in the same way that drugs like opioids or cocaine are, there are concerns about the potential for psychological dependence and the risks associated with long-term use.

Q: Do I need a prescription for peptides?

A: Yes. You should only take peptide hormones prescribed by a doctor or specialized medical professional. Not all peptides are approved by the Food and Drug Administration (FDA), and they are not approved for over-the-counter self-treatment.

Q: Is retinol a peptide?

A: The Answer is no. Retinol, a form of Vitamin A, is excellent for exfoliation and can lead to clearer skin and brighter complexions. However, it requires caution when used in the sun and can take months to see results.

Q: Is retinol better than peptides?

A: Choosing between peptides and retinol depends on your skincare goals, skin type, and tolerance. If you have sensitive skin or are looking for a more gradual approach, peptides might be the better choice. On the other hand, if you're seeking faster and more dramatic results, retinol could be your go-to option.

Q: Can I use peptides everyday?

A: The key to getting the most benefit out of peptides is incorporating them into your daily skincare routine. Apply peptide products to your skin twice a day – once in the morning and once at night. To prep the skin, double cleanse your face.

As one of the most professional peptides manufacturers in China, we're featured by good service and punctual delivery. Please rest assured to buy high quality peptides at competitive price from our factory.

Bivalirudin, Acetyl Tetrapeptide 5, Peptides